SCRAPIE AMYLOID PRECURSOR PROTEIN Meaning and
Definition
-
Scrapie Amyloid Precursor Protein (PrPSc) is a specific protein associated with the transmissible spongiform encephalopathies (TSEs) class of neurodegenerative diseases. It is a modified form of the normal cellular prion protein (PrPC), which undergoes a conformational change leading to the conversion of its structure into an abnormal, insoluble, and aggregated form. This aggregated form of PrPSc is resistant to typical proteases and accumulates in the central nervous system, particularly in the brain.
Scrapie Amyloid Precursor Protein is primarily associated with scrapie, a TSE disease affecting sheep and goats, but similar forms of amyloid proteins have been identified in other TSEs such as bovine spongiform encephalopathy (BSE) in cattle and Creutzfeldt-Jakob disease (CJD) in humans.
The aggregation and accumulation of PrPSc in the brain are believed to be central to the pathogenesis of TSEs. The abnormal protein induces a cascade of events leading to neuronal death and the formation of characteristic spongiform lesions in brain tissue. Importantly, PrPSc possesses the ability to convert the normal cellular prion protein into its misfolded form, perpetuating the disease process.
Scrapie Amyloid Precursor Protein has been extensively studied in the field of prion research due to its role in the development and transmission of TSEs. Understanding the molecular mechanisms underlying the conversion of PrPC to PrPSc is crucial for the development of diagnostic tests, therapeutics, and prevention strategies for TSEs.
Common Misspellings for SCRAPIE AMYLOID PRECURSOR PROTEIN
- acrapie amyloid precursor protein
- zcrapie amyloid precursor protein
- xcrapie amyloid precursor protein
- dcrapie amyloid precursor protein
- ecrapie amyloid precursor protein
- wcrapie amyloid precursor protein
- sxrapie amyloid precursor protein
- svrapie amyloid precursor protein
- sfrapie amyloid precursor protein
- sdrapie amyloid precursor protein
- sceapie amyloid precursor protein
- scdapie amyloid precursor protein
- scfapie amyloid precursor protein
- sctapie amyloid precursor protein
- sc5apie amyloid precursor protein
- sc4apie amyloid precursor protein
- scrzpie amyloid precursor protein
- scrspie amyloid precursor protein
- scrwpie amyloid precursor protein
- scrqpie amyloid precursor protein
Infographic
Add the infographic to your website:
