WHOLE CELL RECORDING Meaning and
Definition
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Whole cell recording is a technique used in electrophysiology to study the electrical activity of individual cells. It involves making a tight seal between a glass micropipette electrode and a living cell membrane, allowing for direct measurement of the cell's electrical properties. This method provides detailed information about the cell's electrical behavior, including ion channels, membrane potential, synaptic activity, and other intrinsic properties.
The process of whole cell recording begins by positioning the micropipette electrode near the target cell and applying gentle pressure to form a seal. Once a seal is successfully formed, the electrode penetrates the cell membrane, establishing an electrical connection. This allows researchers to manipulate the electrical conditions inside the cell and observe changes in response.
Whole cell recording offers several advantages over other electrophysiology methods. It enables the investigation of cells within intact tissue, allowing for a more natural physiological environment. Additionally, it provides high-resolution recordings, capturing both large and small electrical signals with excellent fidelity. This technique is widely used in neuroscience and cell biology research to explore the electrical properties of various cell types and investigate their roles in diseases and normal physiological processes.
Overall, whole cell recording is a powerful technique that provides valuable insights into cellular function and electrical properties by allowing direct measurements of intracellular electrical activity.
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