TRANSNEURONAL RETROGRADE DEGENERATIONS Meaning and
Definition
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Transneuronal retrograde degenerations refer to the process of degeneration and eventual cell death in neurons that are connected to and receive signals from a specific target neuron that has been damaged or lost. It is a phenomenon observed in the field of neuroscience where neurons that are functionally linked to a damaged neuron start to degrade and die over time due to the disruption of their normal communication pathways.
This type of degeneration occurs when a target neuron, which normally provides trophic support signals or chemical cues to connected neurons, becomes damaged or dies. Without these essential signals, the connected neurons undergo a series of structural and functional changes that lead to their degeneration and eventual death.
The mechanism behind transneuronal retrograde degeneration is not fully understood, but it is believed to involve a combination of loss of trophic support, changes in neuronal excitability or neurotransmitter release, and alterations in gene expression patterns within the affected neurons. These changes can disrupt the normal functioning and survival of the connected neurons.
Transneuronal retrograde degeneration can be observed in various neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, or ischemic brain injury. Understanding the mechanisms and effects of this phenomenon is crucial for developing potential therapeutic strategies to slow down or even prevent the degeneration of neurons connected to damaged or diseased neurons.
Common Misspellings for TRANSNEURONAL RETROGRADE DEGENERATIONS
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