PYRUVATE DEHYDROGENASE PHOSPHATE PHOSPHATASE Meaning and
Definition
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Pyruvate dehydrogenase phosphate phosphatase is an enzyme that belongs to the category of phosphatases and is involved in the regulation of pyruvate dehydrogenase complex (PDC) activity, an important enzyme complex that plays a crucial role in cellular energy metabolism. The enzyme acts by catalyzing the dephosphorylation of a phosphate group from pyruvate dehydrogenase (PDH) using a phosphate molecule as a co-substrate.
The pyruvate dehydrogenase complex is responsible for converting pyruvate, a product of glycolysis, into acetyl-CoA, which enters the citric acid cycle to generate energy through oxidative phosphorylation. Phosphorylation of PDH by kinases inhibits its activity, preventing the conversion of pyruvate to acetyl-CoA and slowing down energy production. Pyruvate dehydrogenase phosphate phosphatase acts as a key regulatory enzyme, reversing this phosphorylation and activating the PDH complex.
The dephosphorylation by pyruvate dehydrogenase phosphate phosphatase restores PDH activity, allowing the conversion of pyruvate to acetyl-CoA and promoting energy production. The enzyme is essential for maintaining normal energy levels in cells, and dysregulation of its activity has been implicated in various metabolic disorders, including diabetes, obesity, and neurodegenerative diseases.
Overall, pyruvate dehydrogenase phosphate phosphatase is a critical enzyme that modulates the activity of the pyruvate dehydrogenase complex, facilitating efficient energy production in cells by regulating the conversion of pyruvate to acetyl-CoA through dephosphorylation of PDH.
Common Misspellings for PYRUVATE DEHYDROGENASE PHOSPHATE PHOSPHATASE
- oyruvate dehydrogenase phosphate phosphatase
- lyruvate dehydrogenase phosphate phosphatase
- -yruvate dehydrogenase phosphate phosphatase
- 0yruvate dehydrogenase phosphate phosphatase
- ptruvate dehydrogenase phosphate phosphatase
- pgruvate dehydrogenase phosphate phosphatase
- phruvate dehydrogenase phosphate phosphatase
- puruvate dehydrogenase phosphate phosphatase
- p7ruvate dehydrogenase phosphate phosphatase
- p6ruvate dehydrogenase phosphate phosphatase
- pyeuvate dehydrogenase phosphate phosphatase
- pyduvate dehydrogenase phosphate phosphatase
- pyfuvate dehydrogenase phosphate phosphatase
- pytuvate dehydrogenase phosphate phosphatase
- py5uvate dehydrogenase phosphate phosphatase
- py4uvate dehydrogenase phosphate phosphatase
- pyryvate dehydrogenase phosphate phosphatase
- pyrhvate dehydrogenase phosphate phosphatase
- pyrjvate dehydrogenase phosphate phosphatase
- pyrivate dehydrogenase phosphate phosphatase
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