PROTON PHOSPHATE COTRANSPORTERS Meaning and
Definition
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Proton phosphate cotransporters are a class of membrane proteins that facilitate the transport of inorganic phosphate (Pi) ions across cell membranes. They belong to the family of solute carrier proteins, specifically the phosphate transporters (SLC34). These transporters play a crucial role in maintaining phosphate homeostasis in cells by mediating the uptake or efflux of phosphate ions.
Proton phosphate cotransporters work by utilizing the energy generated from the movement of protons (H+) down their concentration gradient. They couple the transport of phosphate ions with the movement of protons across the membrane, allowing phosphate ions to be transported against their electrochemical gradient.
These transporters are found in various tissues and cell types, including the intestinal epithelial cells, renal tubules, and bone cells. In the intestine, they are responsible for the absorption of dietary phosphate from the intestine into the bloodstream. In the kidneys, they help regulate phosphate reabsorption from the glomerular filtrate, ensuring its proper excretion or retention. Additionally, proton phosphate cotransporters are involved in phosphate reabsorption in bone cells, aiding in bone mineralization and growth.
Dysfunction or mutations in proton phosphate cotransporters can lead to various disorders, including hypophosphatemia (low phosphate levels) or hyperphosphatemia (excessive phosphate levels), which can affect bone mineralization, energy metabolism, and overall cellular function. These transporters are also targets for therapeutic interventions in the treatment of phosphate-related disorders.
Common Misspellings for PROTON PHOSPHATE COTRANSPORTERS
- oroton phosphate cotransporters
- lroton phosphate cotransporters
- -roton phosphate cotransporters
- 0roton phosphate cotransporters
- peoton phosphate cotransporters
- pdoton phosphate cotransporters
- pfoton phosphate cotransporters
- ptoton phosphate cotransporters
- p5oton phosphate cotransporters
- p4oton phosphate cotransporters
- priton phosphate cotransporters
- prkton phosphate cotransporters
- prlton phosphate cotransporters
- prpton phosphate cotransporters
- pr0ton phosphate cotransporters
- pr9ton phosphate cotransporters
- proron phosphate cotransporters
- profon phosphate cotransporters
- progon phosphate cotransporters
- proyon phosphate cotransporters
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