PROTO ONCOGENE PROTEIN FMS Meaning and
Definition
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Proto-oncogene protein fms, also known as FMS-like tyrosine kinase 3 (FLT3), is a protein that is coded by the FLT3 gene. It is a receptor tyrosine kinase that plays a crucial role in the regulation of cell proliferation, differentiation, and survival. The protein belongs to the class III receptor tyrosine kinase family and is primarily expressed on the surface of hematopoietic stem cells and progenitor cells.
Proto-oncogene protein fms is considered a proto-oncogene because it has the potential to become an oncogene, promoting the development of cancer. Mutations or alterations in the FLT3 gene can lead to the constitutive activation of the protein, resulting in uncontrolled cell growth and proliferation. Such mutations are commonly observed in acute myeloid leukemia (AML) and are associated with a poor prognosis.
As a receptor tyrosine kinase, proto-oncogene protein fms functions by binding to its ligand, hematopoietic growth factor FLT3 ligand (FL), and initiating a signaling cascade that activates various downstream pathways, including the MAPK and PI3K/Akt pathways. These pathways regulate important cellular processes such as cell division, differentiation, and survival. Aberrant activation of these signaling pathways due to FLT3 mutations can disrupt normal cellular homeostasis and contribute to tumor formation and progression.
Targeting proto-oncogene protein fms has emerged as a potential therapeutic strategy in treating FLT3-driven cancers, such as AML. Inhibition of the protein's kinase activity using small molecule inhibitors has shown promise in clinical trials by effectively suppressing leukemia cell growth and improving patient outcomes.
Common Misspellings for PROTO ONCOGENE PROTEIN FMS
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