How Do You Spell POLYMERIC IG RECEPTOR?

1. The polymeric Ig receptor (pIgR) is a protein found in mucosal epithelial cells that plays a significant role in the transport of immunoglobulins (antibodies) across epithelial barriers. It is mainly responsible for the transcytosis of polymeric immunoglobulin A (IgA) across mucosal surfaces, such as those found in the respiratory, intestinal, and urogenital tracts.

   The pIgR is a type I transmembrane protein composed of a large extracellular portion, a transmembrane domain, and a short cytoplasmic tail. It is expressed primarily on the basolateral surface of epithelial cells where it binds to the immunoglobulin, facilitating its transport to the luminal surface.

   When the pIgR binds to polymeric IgA or IgM in the bloodstream, it forms a complex that is internalized by endocytosis by the epithelial cell. The complex is then transported across the cell, and finally, the receptor becomes proteolytically cleaved, releasing the bound immunoglobulin into the luminal compartment.

   This mechanism of antibody transport mediated by the pIgR provides an important defense mechanism in mucosal immunity, as it allows for the efficient delivery of antibodies to mucosal surfaces, where they can neutralize pathogens and prevent infections. Additionally, pIgR also plays a role in the removal of pathogens and toxins from mucosal surfaces by transcytosis.

Common Misspellings for POLYMERIC IG RECEPTOR

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