PHOSPHORIBOSYL PYROPHOSPHATE AMIDOTRANSFERASE Meaning and
Definition
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Phosphoribosyl pyrophosphate amidotransferase, also known as PRPP amidotransferase, is an essential enzyme involved in the biosynthesis of nucleotides, which are the building blocks of DNA and RNA. It catalyzes a key step in the pathway that converts ribose-5-phosphate (R5P) into phosphoribosyl pyrophosphate (PRPP), an important precursor molecule for nucleotide synthesis.
PRPP amidotransferase plays a crucial role in maintaining nucleotide balance within cells by controlling the production of purine nucleotides. The enzyme achieves this by catalyzing the transfer of the amido group from glutamine to PRPP, resulting in the formation of 5-phosphoribosylamine. This reaction is the first committed step in the de novo synthesis of purine nucleotides.
The enzyme is comprised of two catalytic subunits, known as the glutaminase domain and the phosphoribosyltransferase domain, as well as two regulatory subunits. The glutaminase domain hydrolyzes glutamine into glutamate and ammonia, providing the amido group necessary for the subsequent transfer reaction.
Due to its pivotal role in nucleotide biosynthesis, any dysfunction or deficiency in PRPP amidotransferase can lead to various genetic disorders, such as Lesch-Nyhan syndrome, which is characterized by overproduction of uric acid and neurological abnormalities.
Understanding the structure and function of PRPP amidotransferase could have implications in the development of therapeutic agents for diseases associated with improper nucleotide metabolism or regulation.
Common Misspellings for PHOSPHORIBOSYL PYROPHOSPHATE AMIDOTRANSFERASE
- ohosphoribosyl pyrophosphate amidotransferase
- lhosphoribosyl pyrophosphate amidotransferase
- -hosphoribosyl pyrophosphate amidotransferase
- 0hosphoribosyl pyrophosphate amidotransferase
- pgosphoribosyl pyrophosphate amidotransferase
- pbosphoribosyl pyrophosphate amidotransferase
- pnosphoribosyl pyrophosphate amidotransferase
- pjosphoribosyl pyrophosphate amidotransferase
- puosphoribosyl pyrophosphate amidotransferase
- pyosphoribosyl pyrophosphate amidotransferase
- phisphoribosyl pyrophosphate amidotransferase
- phksphoribosyl pyrophosphate amidotransferase
- phlsphoribosyl pyrophosphate amidotransferase
- phpsphoribosyl pyrophosphate amidotransferase
- ph0sphoribosyl pyrophosphate amidotransferase
- ph9sphoribosyl pyrophosphate amidotransferase
- phoaphoribosyl pyrophosphate amidotransferase
- phozphoribosyl pyrophosphate amidotransferase
- phoxphoribosyl pyrophosphate amidotransferase
- phodphoribosyl pyrophosphate amidotransferase
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