PASSIVE CUTANEOUS ANAPHYLAXIS Meaning and
Definition
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Passive Cutaneous Anaphylaxis (PCA) is a laboratory technique used to evaluate the allergic reactions in animals. Specifically, it is a method to measure the presence and severity of type I hypersensitivity reactions, commonly known as immediate hypersensitivity reactions or allergies.
In PCA, an antigen that provokes an allergic response is administered to an animal, often a laboratory mouse. The antigen triggers the production and release of specific immunoglobulin E (IgE) antibodies by the animal's immune system. These IgE antibodies then bind to mast cells present in the skin. Subsequently, a secondary injection of the same antigen is given, leading to the antigen-antibody complexes formed between the IgE antibodies and mast cells. This interaction triggers the release of various inflammatory mediators that cause visible physiological changes in the animal's skin.
The characteristic response observed in PCA is a localized skin reaction, such as erythema (redness), swelling, and vasodilation, which can be measured quantitatively. These reactions are indicative of the hypersensitivity response and provide information about the severity and specificity of the allergic reaction.
PCA is a valuable tool in scientific research, often employed to study the pathophysiology of various allergic conditions. It helps identify potential allergens, evaluate the efficacy of anti-allergic drugs, investigate the role of immune cells and molecules in allergic reactions, and develop immunotherapeutic strategies for allergic diseases.
Common Misspellings for PASSIVE CUTANEOUS ANAPHYLAXIS
- oassive cutaneous anaphylaxis
- lassive cutaneous anaphylaxis
- -assive cutaneous anaphylaxis
- 0assive cutaneous anaphylaxis
- pzssive cutaneous anaphylaxis
- psssive cutaneous anaphylaxis
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- pqssive cutaneous anaphylaxis
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- pazsive cutaneous anaphylaxis
- paxsive cutaneous anaphylaxis
- padsive cutaneous anaphylaxis
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- pawsive cutaneous anaphylaxis
- pasaive cutaneous anaphylaxis
- paszive cutaneous anaphylaxis
- pasxive cutaneous anaphylaxis
- pasdive cutaneous anaphylaxis
- paseive cutaneous anaphylaxis
- paswive cutaneous anaphylaxis
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