HISTIDINOL PHOSPHATE PHOSPHATASE Meaning and
Definition
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Histidinol Phosphate Phosphatase, also known as HPP, is an enzyme that catalyzes a biochemical reaction in living organisms. Specifically, it is responsible for the dephosphorylation of histidinol phosphate to form histidinol.
Histidinol phosphate, which is the substrate for HPP, is an intermediate compound produced during the biosynthesis of histidine, an essential amino acid. The dephosphorylation reaction carried out by HPP is a crucial step in the histidine biosynthetic pathway, as it leads to the formation of histidinol. Histidinol is further converted into histidine through subsequent enzymatic reactions.
The activity of histidinol phosphate phosphatase is tightly regulated in cells to maintain optimal levels of histidine. This regulation is achieved through feedback inhibition, where high concentrations of histidine act as inhibitors for the enzyme. This feedback mechanism ensures that histidine synthesis is only upregulated when levels of the amino acid are low in the cell.
The catalytic mechanism of HPP involves the transfer of a phosphate group from the histidinol phosphate substrate to a water molecule, resulting in the release of inorganic phosphate and the formation of histidinol. The enzyme is typically metal-dependent, requiring divalent metal cations such as manganese or magnesium for its activity.
Overall, histidinol phosphate phosphatase plays a crucial role in the biosynthesis of histidine, an important amino acid involved in various physiological processes in living organisms.
Common Misspellings for HISTIDINOL PHOSPHATE PHOSPHATASE
- gistidinol phosphate phosphatase
- bistidinol phosphate phosphatase
- nistidinol phosphate phosphatase
- jistidinol phosphate phosphatase
- uistidinol phosphate phosphatase
- yistidinol phosphate phosphatase
- hustidinol phosphate phosphatase
- hjstidinol phosphate phosphatase
- hkstidinol phosphate phosphatase
- hostidinol phosphate phosphatase
- h9stidinol phosphate phosphatase
- h8stidinol phosphate phosphatase
- hiatidinol phosphate phosphatase
- hiztidinol phosphate phosphatase
- hixtidinol phosphate phosphatase
- hidtidinol phosphate phosphatase
- hietidinol phosphate phosphatase
- hiwtidinol phosphate phosphatase
- hisridinol phosphate phosphatase
- hisfidinol phosphate phosphatase
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