APOLIPOPROTEIN E RECEPTOR Meaning and
Definition
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Apolipoprotein E receptor is a type of protein found on the cell surface that plays a crucial role in the regulation of cholesterol metabolism and lipid homeostasis. It serves as a receptor for apolipoprotein E (apoE) and is primarily involved in the uptake and clearance of lipoprotein particles from the bloodstream.
Apolipoprotein E receptor is commonly referred to as LDL receptor-related protein 1 (LRP1) due to its structural similarities with the low-density lipoprotein (LDL) receptor. LRP1 is widely expressed in various tissues, including the liver, brain, kidney, and adipose tissue. It is involved in the clearance of not only LDL cholesterol but also other lipoproteins such as chylomicron remnants and VLDL (very low-density lipoprotein) particles.
The binding of apoE to its receptor triggers internalization and subsequent degradation of the lipoprotein particle within the cell. This process helps regulate cholesterol levels within cells and prevents the accumulation of lipoproteins in the bloodstream, which is associated with increased cardiovascular disease risk. Additionally, the apoE receptor is involved in numerous other cellular processes, such as cell signaling, cell migration, and the clearance of cellular waste products.
Overall, the apolipoprotein E receptor plays a critical role in maintaining cholesterol and lipid balance within the body, highlighting its importance for overall cardiovascular health and lipid metabolism.
Common Misspellings for APOLIPOPROTEIN E RECEPTOR
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