AMPA S ISOMER Meaning and
Definition
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AMPA S isomer refers to the S-enantiomer of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA). This class of compounds is a subtype of glutamate receptors and is involved in the transmission of excitatory signals in the brain. AMPA S isomer is characterized by its specific molecular structure and its interaction with the AMPA receptor.
The AMPA S isomer has a crucial role in regulating synaptic plasticity, which is the ability of the connections between brain cells to change and adapt. It is a major player in the process of long-term potentiation (LTP), which is essential for learning and memory formation. The isomer binds to the AMPA receptor at the synapse, leading to the activation of ion channels and subsequent influx of calcium ions into the neuron. This influx of calcium triggers a cascade of biochemical events that enhance the strength of the synaptic connection.
Furthermore, the AMPA S isomer is known to mediate fast excitatory synaptic transmission in the brain. It is involved in the modulation of neuronal activity, influencing processes such as neuronal maturation, synaptic efficacy, and synaptic plasticity. Dysfunction of AMPA S isomer has been implicated in various neurological and neuropsychiatric disorders, including Alzheimer's disease, epilepsy, and schizophrenia.
In conclusion, AMPA S isomer is a specific enantiomer of AMPA that plays a vital role in synaptic transmission and synaptic plasticity in the brain. Its activation and modulation are essential for normal brain function and cognitive processes.
